Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites

Signal Transduction in Host Cells by a Glycosylphosphatidyllnositol Toxin of Malaria

In this study, we have identified a dominant glycolipid toxin of Plasmodium fakiparum. It is a glycosylphosphatidylinositol (GPI). The parasite GPI moiety, free or associated with protein, induces tumor necrosis factor and interleukin I production by macrophages and regulates glucose metabolism in adipocytes. Deacylation with specific pbospholipases abolishes cytokine induction, as do inhibitor...

Effects of Cryptolepine, 2, 7, dibromocryptolepine and standard drugs on hemoglobin accumulation in cultured Malaria parasites

Cryptolepine is the major alkaloidal constituent of the West African climbing shrub Cryptolepis sanguinolenta, a species used in traditional medicine for the treatment of malaria and a number of other infectious diseases. Cryptolepine and a number of its synthetic analogues have been shown to have potent antiplasmodial activities using P. falciparum lactate dehydrogenase assay (PfLDH). Intraery...

Transmission Dynamics of Malaria in Human Host: a Neuro-Fuzzy Approach

The Expression of Signal Regulatory Protein-alpha in Normal and Osteoarthritic Human Articular Cartilage and Its Involvement in Chondrocyte Mechano-transduction Response

Signal regulatory proteins (SIRP) belong to immunoglobulin super family (IgSF) and relate to integrin signaling cascades. It has been shown that SIRPa is expressed in a variety of cells including myeloid cells and neurons. In the present study the expression of this IgSF member in articular chondrocytes was investigated. Methods: Using a panel of anti-SIRPalpha antibodies, immunohistochemistry...

Effects of Cryptolepine, 2, 7, dibromocryptolepine and standard drugs on hemoglobin accumulation in cultured Malaria parasites

Cryptolepine is the major alkaloidal constituent of the West African climbing shrub Cryptolepis sanguinolenta, a species used in traditional medicine for the treatment of malaria and a number of other infectious diseases. Cryptolepine and a number of its synthetic analogues have been shown to have potent antiplasmodial activities using P. falciparum lactate dehydrogenase assay (PfLDH). Intraery...